Receptor "cross talk" in innate immunity.

TLR Cross-talk Confers Specificity to Innate Immunity

Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively uniqu...

Infection Trypanosoma cruzi Regulates Innate and Adaptive Immunity in C5a and Bradykinin Receptor Cross-Talk

A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.

Neutrophils and complement are key sentinels of innate immunity and mediators of acute inflammation. Recent studies have suggested that inflammatory processes modulate thrombogenic pathways. To date, the potential cross-talk between innate immunity and thrombosis and the precise molecular pathway by which complement and neutrophils trigger the coagulation process have remained elusive. In this ...

Regulatory T-cell compartmentalization and trafficking.

CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-presenting cells (APCs) and T cells, is crucial for ensuring suppression by Tr...

Par-complex aPKC and Par3 cross-talk with innate immunity NF-kB pathway in epithelial cells